Title : CVB3-Mediated Mitophagy Plays an Important Role in Viral Replication via Abrogation of Interferon Pathways.

Pub. Date : 2021

PMID : 34295842






1 Functional Relationships(s)
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1 Rapamycin or carbonyl cyanide m-chlorophenyl hydrazone (CCCP) treatment led to increased CVB3 RNA copy number in a dose-dependent manner, suggesting enhanced viral replication via autophagy/mitophagy activation, whereas knockdown of PTEN-induced putative kinase protein 1(PINK1) led to impaired mitophagy and subsequent reduction in viral replication. Carbonyl Cyanide m-Chlorophenyl Hydrazone PTEN induced kinase 1 Homo sapiens