Pub. Date : 2021 Nov
PMID : 34292591
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enhanced ammonia detoxification to urea in hepatocytes transduced with human aquaporin-8 gene. | Ammonia | aquaporin 8 | Homo sapiens |
| 2 | Hepatocyte mitochondrial aquaporin-8 (AQP8) channels have been involved in ammonia-derived ureagenesis. | Ammonia | aquaporin 8 | Homo sapiens |
| 3 | Hepatocyte mitochondrial aquaporin-8 (AQP8) channels have been involved in ammonia-derived ureagenesis. | Ammonia | aquaporin 8 | Homo sapiens |
| 4 | Using primary cultured rat hepatocytes, we first confirmed the mitochondrial expression of hAQP8 and then, using unlabeled or 15 N-labeled ammonia, we demonstrated that the urea synthesis was significantly enhanced in hAQP8-transduced hepatocytes. | Ammonia | aquaporin 8 | Homo sapiens |
| 5 | Studies using isolated hAQP8-expressing mitochondria also showed an increased ammonia metabolism. | Ammonia | aquaporin 8 | Homo sapiens |
| 6 | hAQP8 transduction was able to recover the impaired ammonia-derived ureagenesis in hepatotoxin-treated hepatocytes. | Ammonia | aquaporin 8 | Homo sapiens |
| 7 | Our data suggest that mitochondrially-expressed hAQP8 enhances and improves hepatocyte ammonia conversion to urea, a finding with potential therapeutic implications for liver disease with impaired ammonia detoxification. | Ammonia | aquaporin 8 | Homo sapiens |
| 8 | Our data suggest that mitochondrially-expressed hAQP8 enhances and improves hepatocyte ammonia conversion to urea, a finding with potential therapeutic implications for liver disease with impaired ammonia detoxification. | Ammonia | aquaporin 8 | Homo sapiens |