Pub. Date : 2021
PMID : 34290611
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP3A5 Genotype-Dependent Drug-Drug Interaction Between Tacrolimus and Nifedipine in Chinese Renal Transplant Patients. | Nifedipine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | Nifedipine, frequently prescribed for hypertension, is a competitive CYP3A5 inhibitor which can inhibit tacrolimus metabolism. | Nifedipine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | The objective of this study was to investigate whether CYP3A5 genotype could influence tacrolimus-nifedipine DDI in Chinese renal transplant patients. | Nifedipine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 4 | Results: In this study, a significant DDI between tacrolimus and nifedipine with respect to the CYP3A5*3 polymorphism was confirmed. | Nifedipine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 5 | Discussion: A CYP3A5 genotype-dependent DDI was found between tacrolimus and nifedipine. | Nifedipine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 6 | Therefore, personalized therapy accounting for CYP3A5 genotype detection as well as therapeutic drug monitoring are necessary for renal transplant patients when treating with tacrolimus and nifedipine. | Nifedipine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |