Pub. Date : 2021 Jul
PMID : 34290089
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nuclear NAD+ homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells. | NAD | nicotinamide nucleotide adenylyltransferase 1 | Homo sapiens |
| 2 | We integrated whole-genome CRISPR screening and pan-cancer genetic dependency mapping to identify NAMPT and NMNAT1 as AML dependencies governing NAD+ biosynthesis. | NAD | nicotinamide nucleotide adenylyltransferase 1 | Homo sapiens |
| 3 | While both NAMPT and NMNAT1 were required for AML, the presence of NAD+ precursors bypassed the dependence of AML on NAMPT but not NMNAT1, pointing to NMNAT1 as a gatekeeper of NAD+ biosynthesis. | NAD | nicotinamide nucleotide adenylyltransferase 1 | Homo sapiens |
| 4 | While both NAMPT and NMNAT1 were required for AML, the presence of NAD+ precursors bypassed the dependence of AML on NAMPT but not NMNAT1, pointing to NMNAT1 as a gatekeeper of NAD+ biosynthesis. | NAD | nicotinamide nucleotide adenylyltransferase 1 | Homo sapiens |
| 5 | While both NAMPT and NMNAT1 were required for AML, the presence of NAD+ precursors bypassed the dependence of AML on NAMPT but not NMNAT1, pointing to NMNAT1 as a gatekeeper of NAD+ biosynthesis. | NAD | nicotinamide nucleotide adenylyltransferase 1 | Homo sapiens |
| 6 | Deletion of NMNAT1 reduced nuclear NAD+, activated p53, and increased venetoclax sensitivity. | NAD | nicotinamide nucleotide adenylyltransferase 1 | Homo sapiens |
| 7 | Our findings identify NMNAT1 as a previously unidentified therapeutic target that maintains NAD+ for AML progression and chemoresistance. | NAD | nicotinamide nucleotide adenylyltransferase 1 | Homo sapiens |