Pub. Date : 2021 Jun 20
PMID : 34284854
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphorylation of Cofilin-1 Enhances Paclitaxel Resistance of Epithelial Ovarian Cancer Cells by Inhibiting Apoptosis. | Paclitaxel | cofilin 1 | Homo sapiens |
| 2 | Objective: To investigate the molecular mechanism of high phosphorylation levels of cofilin-1 (p-CFL-1) associated with paclitaxel resistance in epithelial ovarian cancer (EOC) cells. | Paclitaxel | cofilin 1 | Homo sapiens |
| 3 | Objective: To investigate the molecular mechanism of high phosphorylation levels of cofilin-1 (p-CFL-1) associated with paclitaxel resistance in epithelial ovarian cancer (EOC) cells. | Paclitaxel | cofilin 1 | Homo sapiens |
| 4 | Results: High levels of p-CFL-1 were observed in EOC cells that survived treatment with high doses of paclitaxel. | Paclitaxel | cofilin 1 | Homo sapiens |
| 5 | Cytoplasmic accumulation of p-CFL-1 inhibited paclitaxel-induced mitochondrial apoptosis. | Paclitaxel | cofilin 1 | Homo sapiens |
| 6 | SSH-1 silencing mediated CFL-1 phosphorylation in paclitaxel-resistant SKOV3 cells. | Paclitaxel | cofilin 1 | Homo sapiens |
| 7 | Conclusion: The SSH-1/p-CFL-1 signaling pathway mediates paclitaxel resistance by apoptosis inhibition in EOC and is expected to be a potential prognostic predictor. | Paclitaxel | cofilin 1 | Homo sapiens |