Title : Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission.

Pub. Date : 2021 Oct 1

PMID : 34284042






1 Functional Relationships(s)
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1 Furthermore, alpha5-NAM inhibition of the GABAAR tonic current in mature neurons is maintained after 2-day alpha5-NAM treatment, suggesting reduced tolerance liability, in contrast to other clinically relevant GABAAR-targeting drugs such as benzodiazepines. Benzodiazepines gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus