Title : Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers.

Pub. Date : 2022 Apr

PMID : 34267345






2 Functional Relationships(s)
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1 Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers. Itraconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 In this study, we investigated the effects of CYP3A inhibitor itraconazole and CYP3A inducer rifampicin on the pharmacokinetics of almonertinib and HAS-719 in 64 healthy volunteers. Itraconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens