Title : Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer.

Pub. Date : 2021 Jul 6

PMID : 34262644






2 Functional Relationships(s)
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1 In both the Kras LSL.G12D/+; Pdx1-Cre (KC) mouse model of caerulein-induced inflammatory pancreatitis and the Kras LSL.G12D/+; Tp53 R172H/+; Pdx1-Cre (KPC) mouse model of advanced pancreatic cancer, mebendazole significantly reduced pancreas weight, dysplasia and intraepithelial neoplasia formation, compared to controls. Mebendazole Kirsten rat sarcoma viral oncogene homolog Mus musculus
2 In both the Kras LSL.G12D/+; Pdx1-Cre (KC) mouse model of caerulein-induced inflammatory pancreatitis and the Kras LSL.G12D/+; Tp53 R172H/+; Pdx1-Cre (KPC) mouse model of advanced pancreatic cancer, mebendazole significantly reduced pancreas weight, dysplasia and intraepithelial neoplasia formation, compared to controls. Mebendazole Kirsten rat sarcoma viral oncogene homolog Mus musculus