Pub. Date : 1987 Dec
PMID : 3425755
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Endogenous prostaglandins selectively mask large arteriole constriction to angiotensin II. | Prostaglandins | angiotensinogen | Rattus norvegicus |
| 2 | However, after the inhibition of local prostaglandin synthesis with either mefenamic acid or indomethacin, both A1 and A2, but not the venules, gave a significant constrictor response to angiotensin II (10(-6) M). | Prostaglandins | angiotensinogen | Rattus norvegicus |
| 3 | These observations indicate that endogenous prostaglandins exert a significant dilator influence on the larger arterioles, that this dilator influence appears to oppose the constrictor effect of angiotensin II, and that angiotensin II acts on specific receptors to induce synthesis and/or release of dilator prostaglandins in large arterioles. | Prostaglandins | angiotensinogen | Rattus norvegicus |
| 4 | These observations indicate that endogenous prostaglandins exert a significant dilator influence on the larger arterioles, that this dilator influence appears to oppose the constrictor effect of angiotensin II, and that angiotensin II acts on specific receptors to induce synthesis and/or release of dilator prostaglandins in large arterioles. | Prostaglandins | angiotensinogen | Rattus norvegicus |