Pub. Date : 1987 Dec
PMID : 3425722
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High-performance liquid chromatography (HPLC) analysis revealed that [3,4,5-3H-Phe3,Arg8]vasopressin ([3H]AVP) was not degraded by isolated renal brush-border membranes or by a cortical lysosomal fraction in vitro; however, in the presence of 1 mM reduced glutathione, [3H]AVP was degraded by both preparations. | Tritium | arginine vasopressin | Homo sapiens |
| 2 | High-performance liquid chromatography (HPLC) analysis revealed that [3,4,5-3H-Phe3,Arg8]vasopressin ([3H]AVP) was not degraded by isolated renal brush-border membranes or by a cortical lysosomal fraction in vitro; however, in the presence of 1 mM reduced glutathione, [3H]AVP was degraded by both preparations. | Tritium | arginine vasopressin | Homo sapiens |
| 3 | Following microinfusion of [3H]AVP into proximal tubules, 15.7% of the label was absorbed. | Tritium | arginine vasopressin | Homo sapiens |
| 4 | Five and fifteen minutes after infusion of [3H]AVP, sequestration of total label in proximal tubules was 4.5 and 2.1%, respectively, and quantitative electron microscope autoradiography revealed accumulation of grains over apical endocytic vacuoles and lysosomes consistent with endocytic uptake and rapid lysosomal degradation of AVP and/or a large metabolite. | Tritium | arginine vasopressin | Homo sapiens |
| 5 | Five and fifteen minutes after infusion of [3H]AVP, sequestration of total label in proximal tubules was 4.5 and 2.1%, respectively, and quantitative electron microscope autoradiography revealed accumulation of grains over apical endocytic vacuoles and lysosomes consistent with endocytic uptake and rapid lysosomal degradation of AVP and/or a large metabolite. | Tritium | arginine vasopressin | Homo sapiens |