Title : capCLIP: a new tool to probe translational control in human cells through capture and identification of the eIF4E-mRNA interactome.

Pub. Date : 2021 Oct 11

PMID : 34255842






2 Functional Relationships(s)
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1 First, we use capCLIP to identify the eIF4E cap-omes in human cells with/without the mTORC1 (mechanistic target of rapamycin, complex 1) inhibitor rapamycin, there being an emerging consensus that rapamycin inhibits translation of TOP (terminal oligopyrimidine) mRNAs by displacing eIF4E from their caps. oligopyrimidine eukaryotic translation initiation factor 4E Homo sapiens
2 First, we use capCLIP to identify the eIF4E cap-omes in human cells with/without the mTORC1 (mechanistic target of rapamycin, complex 1) inhibitor rapamycin, there being an emerging consensus that rapamycin inhibits translation of TOP (terminal oligopyrimidine) mRNAs by displacing eIF4E from their caps. oligopyrimidine eukaryotic translation initiation factor 4E Homo sapiens