Pub. Date : 2021 Aug
PMID : 34246631
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Such sustained p38 MAPK activation increases the activity of cytosolic phospholipase A2 (cPLA2), which catalyzes the release of arachidonic acid, the initial substrate for PGE2 biosynthesis. | Arachidonic Acid | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | Sustained p38 MAPK activation also induces NF-kappaB-mediated increase in expression of cyclooxygenase-2 (COX-2) that is involved in the conversion of arachidonic acid to prostanoids resulting in enhanced biosynthesis and release of PGE2 from neurons. | Arachidonic Acid | mitogen-activated protein kinase 14 | Homo sapiens |