Title : Upregulation of COX-2 and PGE2 Induced by TNF-α Mediated Through TNFR1/MitoROS/PKCα/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts.

Pub. Date : 2021

PMID : 34234507






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Upregulation of COX-2 and PGE2 Induced by TNF-alpha Mediated Through TNFR1/MitoROS/PKCalpha/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts. Dinoprostone mitogen-activated protein kinase 8 Homo sapiens
2 Conclusion: Our results suggested that TNF-alpha-induced COX-2/PGE2 upregulation is mediated through TNFR1-dependent MitoROS/PKCalpha/p38 MAPK and JNK1/2 cascade to activate FoxO1 binding with the COX-2 promoter in HCFs. Dinoprostone mitogen-activated protein kinase 8 Homo sapiens