Pub. Date : 2021
PMID : 34220523
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ten healthy male volunteers (five subjects with the c.421CC and c.421CA genotype, respectively) underwent two consecutive positron emission tomography (PET) scans after intravenous injection of the model ABCB1/ABCG2 substrate (11C)tariquidar. | tariquidar | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 2 | The second PET scan was performed with concurrent intravenous infusion of unlabelled tariquidar to inhibit ABCB1 in order to specifically reveal ABCG2 function.In response to ABCB1 inhibition with unlabelled tariquidar, ABCG2 c.421C > A genotype carriers showed significant increases (as compared to the baseline scan) in retinal radiotracer influx K 1 (+62 +- 57%, p = 0.043) and volume of distribution V T (+86 +- 131%, p = 0.043), but no significant changes were observed in subjects with the c.421C > C genotype. | tariquidar | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 3 | The second PET scan was performed with concurrent intravenous infusion of unlabelled tariquidar to inhibit ABCB1 in order to specifically reveal ABCG2 function.In response to ABCB1 inhibition with unlabelled tariquidar, ABCG2 c.421C > A genotype carriers showed significant increases (as compared to the baseline scan) in retinal radiotracer influx K 1 (+62 +- 57%, p = 0.043) and volume of distribution V T (+86 +- 131%, p = 0.043), but no significant changes were observed in subjects with the c.421C > C genotype. | tariquidar | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 4 | The second PET scan was performed with concurrent intravenous infusion of unlabelled tariquidar to inhibit ABCB1 in order to specifically reveal ABCG2 function.In response to ABCB1 inhibition with unlabelled tariquidar, ABCG2 c.421C > A genotype carriers showed significant increases (as compared to the baseline scan) in retinal radiotracer influx K 1 (+62 +- 57%, p = 0.043) and volume of distribution V T (+86 +- 131%, p = 0.043), but no significant changes were observed in subjects with the c.421C > C genotype. | tariquidar | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |