Title : Promoting Nrf2/Sirt3-Dependent Mitophagy Suppresses Apoptosis in Nucleus Pulposus Cells and Protects against Intervertebral Disc Degeneration.

Pub. Date : 2021

PMID : 34211633






3 Functional Relationships(s)
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1 The results demonstrated that activation of the Nrf2/Sirt3 pathway inhibited tert-butyl hydroperoxide- (TBHP-) induced apoptosis and mitochondrial dysfunction in vitro. tert-Butylhydroperoxide NFE2 like bZIP transcription factor 2 Rattus norvegicus
2 The results demonstrated that activation of the Nrf2/Sirt3 pathway inhibited tert-butyl hydroperoxide- (TBHP-) induced apoptosis and mitochondrial dysfunction in vitro. tert-Butylhydroperoxide NFE2 like bZIP transcription factor 2 Rattus norvegicus
3 In addition to apoptosis, upregulation of the Nrf2/Sirt3 pathway induced by t-BHQ restored TBHP-induced autophagic flux disturbances. tert-Butylhydroperoxide NFE2 like bZIP transcription factor 2 Rattus norvegicus