Pub. Date : 2021
PMID : 34211630
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that TPGS induces apoptosis in K562 cells through H2O2 signaling mechanism comprising the activation of a minimal molecular cascade: the kinase JNK>the transcription factor c-JUN>the activation of BCL-only BH3 proapoptotic protein PUMA>loss of mitochondrial membrane potential (DeltaPsi m)>activation of caspase-3>chromatin condensation>fragmentation of DNA. | Hydrogen Peroxide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |