Title : Differential Reversible and Irreversible Interactions between Benzbromarone and Human Cytochrome P450s 3A4 and 3A5.

Pub. Date : 2021 Sep

PMID : 34210765






1 Functional Relationships(s)
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1 Furthermore, heteroactivation was suppressed by the CYP3A inhibitor ketoconazole in a concentration-dependent manner and decreased with increasing pre-incubation time, implying that activation was incited via binding of parent BBR molecule within the enzymatic active site. Ketoconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens