Pub. Date : 2021 Jun 11
PMID : 34208028
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the mechanism, DNA-PK-Chk2 signaling was activated by ETO treatment; inhibition of this signaling cascade alleviated multiple ETO-induced centrosomes and primary cilia followed by reducing cellular senescence. | Etoposide | checkpoint kinase 2 | Homo sapiens |
| 2 | In the mechanism, DNA-PK-Chk2 signaling was activated by ETO treatment; inhibition of this signaling cascade alleviated multiple ETO-induced centrosomes and primary cilia followed by reducing cellular senescence. | Etoposide | checkpoint kinase 2 | Homo sapiens |
| 3 | Importantly, the inactivation of DNA-PK-Chk2 signaling reduced ETO-triggered autophagy; however, the inhibition of autophagy did not affect DNA-PK-Chk2 activation. | Etoposide | checkpoint kinase 2 | Homo sapiens |
| 4 | Thus, ETO activated the DNA-PK-Chk2 cascade to facilitate autophagy. | Etoposide | checkpoint kinase 2 | Homo sapiens |