Title : β-Ketophosphonates with Pentalenofuran Scaffolds Linked to the Ketone Group for the Synthesis of Prostaglandin Analogs.

Pub. Date : 2021 Jun 24

PMID : 34202639






3 Functional Relationships(s)
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1 The bulky pentalenofurane skeleton is expected to introduce more hindrance in the prostaglandin analogues of type III, greater than that obtained with the bicyclo(3.3.0)oct(a)ene fragments of prostaglandin analogues I and II, to slow down (retard) the inactivation of the prostaglandin analogues by oxidation of 15alpha-OH to the 15-keto group via the 15-PGDH pathway. Prostaglandins 15-hydroxyprostaglandin dehydrogenase Homo sapiens
2 The bulky pentalenofurane skeleton is expected to introduce more hindrance in the prostaglandin analogues of type III, greater than that obtained with the bicyclo(3.3.0)oct(a)ene fragments of prostaglandin analogues I and II, to slow down (retard) the inactivation of the prostaglandin analogues by oxidation of 15alpha-OH to the 15-keto group via the 15-PGDH pathway. Prostaglandins 15-hydroxyprostaglandin dehydrogenase Homo sapiens
3 The bulky pentalenofurane skeleton is expected to introduce more hindrance in the prostaglandin analogues of type III, greater than that obtained with the bicyclo(3.3.0)oct(a)ene fragments of prostaglandin analogues I and II, to slow down (retard) the inactivation of the prostaglandin analogues by oxidation of 15alpha-OH to the 15-keto group via the 15-PGDH pathway. Prostaglandins 15-hydroxyprostaglandin dehydrogenase Homo sapiens