Title : Discovery of Novel Chemical Series of OXA-48 β-Lactamase Inhibitors by High-Throughput Screening.

Pub. Date : 2021 Jun 25

PMID : 34202402






1 Functional Relationships(s)
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1 Importantly, the most potent representative of the latter series (ID2, AC50 = 0.99 muM) inhibited OXA-48 via a reversible and competitive mechanism of action, as demonstrated by biochemical and X-ray studies; furthermore, it slightly improved imipenem"s activity in Escherichia coli ATCC BAA-2523 beta-lactam resistant strain. Imipenem OXA-48 Klebsiella pneumoniae