Pub. Date : 2021 Jun 13
PMID : 34199328
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sildenafil citrate, a widely-used oral therapy for erectile dysfunction, is a cytochrome P3A4 (CYP3A4) enzyme substrate. | Sildenafil Citrate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Sildenafil citrate, a widely-used oral therapy for erectile dysfunction, is a cytochrome P3A4 (CYP3A4) enzyme substrate. | Sildenafil Citrate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Studies have reported that this substrate has an inhibitory effect on CYP3A4 enzymes in long-term cigarette and cannabis smokers, which predominantly mediate the hepatic elimination of sildenafil. | Sildenafil Citrate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |