Title : In Silico and In Cell Hybrid Selection of Nonrapalog Ligands to Allosterically Inhibit the Kinase Activity of mTORC1.

Pub. Date : 2022 Jan 27

PMID : 34191518






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Our studies showed that WRX606 formed a ternary complex with FK506-binding protein-12 (FKBP12) and FKBP-rapamycin-binding (FRB) domain of mTOR, resulting in the allosteric inhibition of mTORC1. Sirolimus CREB regulated transcription coactivator 1 Mus musculus