Title : Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine-hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancer.

Pub. Date : 2021 Dec

PMID : 34187263






1 Functional Relationships(s)
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1 A series of thieno(2,3-d)pyrimidine-based hydroxamic acid hybrids was designed and synthesised as multitarget anti-cancer agents, through incorporating the pharmacophore of EGFR, VEGFR2 into the inhibitory functionality of HDAC6. Hydroxamic Acids epidermal growth factor receptor Homo sapiens