Title : Fisetin Prevents Oxidized Low-density Lipoprotein-Induced Macrophage Foam Cell Formation.

Pub. Date : 2021 Nov 1

PMID : 34173812






2 Functional Relationships(s)
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1 Fisetin could also ameliorate and reduce oxLDL-induced upregulation of SREBP-1 and thereby expression of its downstream liposynthesis genes HMGCR and FAS via inhibiting ROS-induced NLRP3 activation. fisetin fatty acid synthase Homo sapiens
2 In conclusion, fisetin could inhibit foam cell formation by blocking oxLDL induced ROS formation and subsequent NLRP3 activation, thereby inhibiting SREBP-1 and its downstream genes including FAS and HMGCR. fisetin fatty acid synthase Homo sapiens