Pub. Date : 2021 Nov 1
PMID : 34173812
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fisetin could also ameliorate and reduce oxLDL-induced upregulation of SREBP-1 and thereby expression of its downstream liposynthesis genes HMGCR and FAS via inhibiting ROS-induced NLRP3 activation. | fisetin | fatty acid synthase | Homo sapiens |
| 2 | In conclusion, fisetin could inhibit foam cell formation by blocking oxLDL induced ROS formation and subsequent NLRP3 activation, thereby inhibiting SREBP-1 and its downstream genes including FAS and HMGCR. | fisetin | fatty acid synthase | Homo sapiens |