Title : Co-delivery of methotrexate and nicotinamide by cerosomes for topical psoriasis treatment with enhanced efficacy.

Pub. Date : 2021 Aug 10

PMID : 34171426






1 Functional Relationships(s)
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1 Importantly, compared to MTX oral administration, topical application of MTX/NIC cerosomes on imiquimod (IMQ)-induced psoriatic mouse model exhibited a superior performance in ameliorating skin lesions, reducing spleen index and epidermal thickness, and downregulating the mRNA expression levels of proinflammatory cytokines including TNFalpha, IL-23, IL-17A, IL-6, IL-1beta, and IL-22. Niacinamide tumor necrosis factor Mus musculus