Title : Combined EZH2 Inhibition and IKAROS Degradation Leads to Enhanced Antitumor Activity in Diffuse Large B-cell Lymphoma.

Pub. Date : 2021 Oct 1

PMID : 34168051






2 Functional Relationships(s)
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1 The sensitizing effect of IKZF1 loss-of-function was then validated and leveraged for combination treatment with lenalidomide. Lenalidomide IKAROS family zinc finger 1 Homo sapiens
2 Treating cells with tazemetostat and lenalidomide, an immunomodulatory drug that selectively degrades Ikaros and Aiolos, phenocopied the effects of the CRISPR/Cas9 screen. Lenalidomide IKAROS family zinc finger 1 Homo sapiens