Title : Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging.

Pub. Date : 2021 Aug 17

PMID : 34162223






2 Functional Relationships(s)
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1 Observations from aged mice and human samples implicated age-related decline in hepatic Phe catabolism as a key driver of elevated plasma Phe levels and showed increased myocardial PAH-mediated Phe catabolism, a novel signature of cardiac aging. Phenylalanine phenylalanine hydroxylase Homo sapiens
2 They highlight Phe/PAH modulation as a potential therapeutic strategy for age-associated cardiac impairment. Phenylalanine phenylalanine hydroxylase Homo sapiens