CPRiL

3 Functional Relationships(s) Download
	Sentence	Compound Name	Protein Name	Organism
1	Our data show that adenosine and remdesivir triphosphates promote the synthesis of A-less RNAs, as does ppGpp, while amino acid substitutions at the NiRAN-RdRp interface augment activation, suggesting that ligand binding to the NiRAN catalytic site modulates RdRp activity.	remdesivir	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2
2	Our data show that adenosine and remdesivir triphosphates promote the synthesis of A-less RNAs, as does ppGpp, while amino acid substitutions at the NiRAN-RdRp interface augment activation, suggesting that ligand binding to the NiRAN catalytic site modulates RdRp activity.	remdesivir	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2
3	Using this assay, we demonstrate that RdRp is allosterically activated by nontemplating phosphorylated nucleotides, including naturally occurring alarmone ppGpp and synthetic remdesivir triphosphate.	remdesivir	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2