Title : The Synergy of ADAM17-Induced Myocardial Inflammation and Metabolic Lipids Dysregulation During Acute Stress: New Pathophysiologic Insights Into Takotsubo Cardiomyopathy.

Pub. Date : 2021

PMID : 34150874






2 Functional Relationships(s)
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1 Under acute stressful conditions, the hyperstimulation of beta-adrenergic receptors (beta-ARs) resulting from excessive release of catecholamines induces intracellular kinases capable of phosphorylating and activating "A Disintegrin and Metalloprotease 17" (ADAM17), a type-I transmembrane protease that plays a central role in acute myocardial inflammation and metabolic lipids dysregulation which are the main hallmarks of TTC. Catecholamines ADAM metallopeptidase domain 17 Homo sapiens
2 Under acute stressful conditions, the hyperstimulation of beta-adrenergic receptors (beta-ARs) resulting from excessive release of catecholamines induces intracellular kinases capable of phosphorylating and activating "A Disintegrin and Metalloprotease 17" (ADAM17), a type-I transmembrane protease that plays a central role in acute myocardial inflammation and metabolic lipids dysregulation which are the main hallmarks of TTC. Catecholamines ADAM metallopeptidase domain 17 Homo sapiens