Title : DNA damage and oxidant stress activate p53 through differential upstream signaling pathways.

Pub. Date : 2021 Aug 20

PMID : 34144191






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Stabilization and activation of the p53 tumor suppressor are triggered in response to various cellular stresses, including DNA damaging agents and elevated Reactive Oxygen Species (ROS) like H2O2. Hydrogen Peroxide tumor protein p53 Homo sapiens
2 However, H2O2 also induces signaling through stress-activated kinases (SAPK, e.g., JNK and p38MAPK) that can activate p53. Hydrogen Peroxide tumor protein p53 Homo sapiens