Title : Quantitative Exchange NMR-Based Analysis of Huntingtin-SH3 Interactions Suggests an Allosteric Mechanism of Inhibition of Huntingtin Aggregation.

Pub. Date : 2021 Jun 30

PMID : 34137596






1 Functional Relationships(s)
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1 Here we show that binding of Fyn SH3, a small intracellular proline-binding domain, to the first polyproline tract of httex1Q35 inhibits fibril formation by both NMR and a thioflavin T fluorescence assay. Proline FYN proto-oncogene, Src family tyrosine kinase Homo sapiens