Pub. Date : 2021
PMID : 34135764
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protective Effects of Sacubitril/Valsartan on Cardiac Fibrosis and Function in Rats With Experimental Myocardial Infarction Involves Inhibition of Collagen Synthesis by Myocardial Fibroblasts Through Downregulating TGF-beta1/Smads Pathway. | Valsartan | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | Besides, Sac/Val inhibited myocardial TGF-beta1 and p-Smad3 protein expression better than Val. | Valsartan | transforming growth factor, beta 1 | Rattus norvegicus |
| 3 | Besides, Sac/Val inhibited myocardial TGF-beta1 and p-Smad3 protein expression better than Val. | Valsartan | transforming growth factor, beta 1 | Rattus norvegicus |
| 4 | Mechanically, Sac/Val significantly attenuated TGF-beta1-induced proliferation and collagen synthesis of MFs, and inhibit Smad3 phosphorylation and nucleus translocation, and this effect outperformed Val. | Valsartan | transforming growth factor, beta 1 | Rattus norvegicus |