Title : The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity.

Pub. Date : 2021 Jun 15

PMID : 34133924






2 Functional Relationships(s)
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1 Loss of Gpx4 results in excessive accumulation of lipid peroxides and ferroptosis of Treg cells upon T cell receptor (TCR)/CD28 co-stimulation. Lipid Peroxides glutathione peroxidase 4 Homo sapiens
2 Neutralization of lipid peroxides and blockade of iron availability rescue ferroptosis of Gpx4-deficient Treg cells. Lipid Peroxides glutathione peroxidase 4 Homo sapiens