Title : Asporin represses gastric cancer apoptosis via activating LEF1-mediated gene transcription independent of β-catenin.

Pub. Date : 2021 Jul

PMID : 34127813






1 Functional Relationships(s)
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1 The suppression of cell apoptosis by ASPN overexpression could be attenuated by LEF1 knockdown or 100 microM aspirin (PTGS2 inhibitor), and siASPN mediated apoptosis could be rescued by LEF1 ectopic expression or adding recombinant IL6. Aspirin prostaglandin-endoperoxide synthase 2 Homo sapiens