Pub. Date : 2021 Aug 24
PMID : 34124933
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rewiring of lactate-IL-1beta auto-regulatory loop with Clock-Bmal1: A feed-forward circuit in glioma. | Lactic Acid | interleukin 1 alpha | Homo sapiens |
| 2 | Tumor metabolite lactate- mediated increase in pro-inflammatory cytokine IL-1beta was concomitant with elevated levels of core circadian regulators Clock and Bmal1. | Lactic Acid | interleukin 1 alpha | Homo sapiens |
| 3 | Lactate mediated deacetylation of Bmal1 and its interaction with Clock, regulate IL-1beta levels and vice versa. | Lactic Acid | interleukin 1 alpha | Homo sapiens |
| 4 | ChIP-re-ChIP revealed that lactate-IL-1beta crosstalk positively affects co-recruitment of Clock-Bmal1 to these E-box sites. | Lactic Acid | interleukin 1 alpha | Homo sapiens |
| 5 | TCGA data analysis suggested the presence of lactate- IL-1beta-crosstalk in other cancers. | Lactic Acid | interleukin 1 alpha | Homo sapiens |
| 6 | Our findings provide evidence for a potential cancer-specific axis wiring of IL-1beta and LDHA through Clock -Bmal1, the outcome of which is to fuel an IL-1beta-lactate autocrine loop that drives pro-inflammatory and oncogenic signals. | Lactic Acid | interleukin 1 alpha | Homo sapiens |
| 7 | Our findings provide evidence for a potential cancer-specific axis wiring of IL-1beta and LDHA through Clock -Bmal1, the outcome of which is to fuel an IL-1beta-lactate autocrine loop that drives pro-inflammatory and oncogenic signals. | Lactic Acid | interleukin 1 alpha | Homo sapiens |