Title : Memantine ameliorates cognitive deficit in AD mice via enhancement of entorhinal-CA1 projection.

Pub. Date : 2021 Jun 14

PMID : 34120588






2 Functional Relationships(s)
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1 Here we treated APP/PS1 AD mice with a therapeutic dose of memantine (20 mg/kg/day) and examined its underlying mechanisms in ameliorating cognitive defects. Memantine presenilin 1 Mus musculus
2 RESULTS: Memantine significantly improved the acquisition in Morris water maze (MWM) in APP/PS1 mice without affecting the speed of swimming. Memantine presenilin 1 Mus musculus