Pub. Date : 2021 Jun 12
PMID : 34118875
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | beta-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275. | beta-elemene | microRNA 1275 | Homo sapiens |
| 2 | RESULTS: The hyperactive ILK/Akt pathway and dysregulated LncRNA-MIR143HG, which acted as a miR-1275 ceRNA to modulate ILK expression, were suppressed in beta-elemene-treated airway granulation fibroblasts; beta-elemene suppressed the ILK/Akt pathway via the MIR143HG/miR-1275/ILK axis. | beta-elemene | microRNA 1275 | Homo sapiens |
| 3 | RESULTS: The hyperactive ILK/Akt pathway and dysregulated LncRNA-MIR143HG, which acted as a miR-1275 ceRNA to modulate ILK expression, were suppressed in beta-elemene-treated airway granulation fibroblasts; beta-elemene suppressed the ILK/Akt pathway via the MIR143HG/miR-1275/ILK axis. | beta-elemene | microRNA 1275 | Homo sapiens |
| 4 | In vivo application of beta-elemene attenuated airway granulation hyperplasia and alleviated scar stricture, and histological detections suggested that beta-elemene"s effects on the MIR143HG/miR-1275/ILK axis and ILK/Akt pathway were in line with in vitro findings. | beta-elemene | microRNA 1275 | Homo sapiens |
| 5 | The MIR143HG/miR-1275/ILK axis mediates beta-elemene-induced cell cycle arrest and apoptosis of airway granulation fibroblasts by modulating the ILK/Akt pathway, thereby inhibiting airway granulation proliferation and ultimately alleviating airway stenosis. | beta-elemene | microRNA 1275 | Homo sapiens |