Title : Importance of hydrogen peroxide in nitrofurantoin-induced cytotoxicity: evidence from an inbred catalase-deficient strain of mice.

Pub. Date : 1988 Sep

PMID : 3411191






1 Functional Relationships(s)
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1 This model, using genetically defined target cell populations, clearly demonstrates the importance of endogenous catalase in protecting against nitrofurantoin-induced cytotoxicity, suggesting that H2O2 is a critical intermediary in the direct cell injury mediated by the drug. Nitrofurantoin catalase Mus musculus