Title : C2C12 myoblasts are more sensitive to the toxic effects of simvastatin than myotubes and show impaired proliferation and myotube formation.

Pub. Date : 2021 Aug

PMID : 34111424






1 Functional Relationships(s)
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1 Simvastatin impaired the phosphorylation of the insulin receptor (IR beta), Akt ser473 and S6rp, and increased phosphorylation of AMPK thr172 in both myotubes and myoblasts, which was prevented by insulin and mevalonate. Simvastatin AKT serine/threonine kinase 1 Homo sapiens