Title : Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors "leflunomide" and "teriflunomide" in Covid-19: A narrative review.

Pub. Date : 2021 Sep 5

PMID : 34111397






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In target-centered in silico studies, leflunomide showed favorable binding to active site of MPro and spike: ACE2 interface. Leflunomide surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 In artificial-intelligence/machine-learning based studies, leflunomide was among the top 50 ligands targeting spike: ACE2 interaction. Leflunomide surface glycoprotein Severe acute respiratory syndrome coronavirus 2