Title : Iminosugar C-Glycosides Work as Pharmacological Chaperones of NAGLU, a Glycosidase Involved in MPS IIIB Rare Disease*.

Pub. Date : 2021 Aug 5

PMID : 34106504






1 Functional Relationships(s)
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1 Capitalizing on the three-dimensional structures of two modest homoiminosugar-based NAGLU inhibitors in complex with bacterial homolog of NAGLU, CpGH89, we have synthesized a library of 17 six-membered iminosugar- C -glycosides mimicking N -acetyl-D-glucosamine and bearing various pseudo-anomeric substituents of both alpha - and beta -configuration. Acetylglucosamine N-acetyl-alpha-glucosaminidase Homo sapiens