Title : Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis.

Pub. Date : 2021 Jun 7

PMID : 34099711






2 Functional Relationships(s)
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1 We demonstrate that proline/arginine repeat polymers inhibit the folding catalyst activity of PPIA, an abundant molecular chaperone and prolyl isomerase in the brain that is altered in amyotrophic lateral sclerosis. Proline peptidylprolyl isomerase A Homo sapiens
2 NMR spectroscopy reveals that proline/arginine repeat polymers bind to the active site of PPIA. Proline peptidylprolyl isomerase A Homo sapiens