Title : Induction of monoamine oxidase A-mediated oxidative stress and impairment of NRF2-antioxidant defence response by polyphenol-rich fraction of Bergenia ligulata sensitizes prostate cancer cells in vitro and in vivo.

Pub. Date : 2021 Aug 20

PMID : 34097996






1 Functional Relationships(s)
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1 Tumor tissues in PFBL-treated mice showed upregulation of similar mechanism of cell death as observed in isolated PC3 cells i.e., elevation of MAO-A catalytic activity, ROS production accompanied by activation of beta-TrCP-GSK-3beta axis of NRF2 degradation. pfbl monoamine oxidase A Mus musculus