Pub. Date : 2021 Jun 7
PMID : 34096887
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calycosin inhibits breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-beta1. | 7,3'-dihydroxy-4'-methoxyisoflavone | transforming growth factor beta 1 | Homo sapiens |
| 2 | Calycosin treatment inhibited epithelial-mesenchymal transition (EMT) of breast cancer cells by significantly increasing E-cadherin levels and decreasing N-cadherin, Vimentin, CD147, MMP-2, and MMP-9 levels through downregulation of BATF and TGFbeta1. | 7,3'-dihydroxy-4'-methoxyisoflavone | transforming growth factor beta 1 | Homo sapiens |
| 3 | TGFbeta1 knockdown reduced the migration and invasiveness of BATF-overexpressing breast cancer cells, whereas incubation with TGFbeta1 enhanced the migration and invasiveness of calycosin-treated breast cancer cells. | 7,3'-dihydroxy-4'-methoxyisoflavone | transforming growth factor beta 1 | Homo sapiens |
| 4 | Our findings demonstrated that calycosin inhibited EMT and progression of breast cancer cells by suppressing BATF/TGFbeta1 signaling. | 7,3'-dihydroxy-4'-methoxyisoflavone | transforming growth factor beta 1 | Homo sapiens |