Title : Capsaicin and Proton Differently Modulate Activation Kinetics of Mouse Transient Receptor Potential Vanilloid-1 Channel Induced by Depolarization.

Pub. Date : 2021

PMID : 34093200






6 Functional Relationships(s)
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1 TRPV1 is activated by capsaicin, thermal stimuli higher than 43 C, mechanical stress, and protons (H+). Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
2 In the presence of capsaicin, voltage-dependent probability of opening of the TRPV1 channel and its kinetics have been examined, but the characteristics in the low pH remain unclear. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
3 To understand the voltage-dependency of the TRPV1 channel activation, we recorded capsaicin- and proton-induced mouse TRPV1 channel currents in a heterologous expression system. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
4 To understand the voltage-dependency of the TRPV1 channel activation, we recorded capsaicin- and proton-induced mouse TRPV1 channel currents in a heterologous expression system. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
5 These results suggest that the TRPV1 channel slowly drives the feed-forward cycle of pain sensation, and capsaicin and protons differently modulate the voltage-dependent TRPV1 channel gating. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
6 These results suggest that the TRPV1 channel slowly drives the feed-forward cycle of pain sensation, and capsaicin and protons differently modulate the voltage-dependent TRPV1 channel gating. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus