Title : Polyamine-Conjugated Nitroxides Are Efficacious Inhibitors of Oxidative Reactions Catalyzed by Endothelial-Localized Myeloperoxidase.

Pub. Date : 2021 Jun 21

PMID : 34085520






2 Functional Relationships(s)
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1 At this site, MPO mediates endothelial dysfunction by catalytically consuming nitric oxide (NO) and producing reactive oxidants, hypochlorous acid (HOCl) and the nitrogen dioxide radical ( NO2). Nitrogen Dioxide myeloperoxidase Homo sapiens
2 Nitroxides also differentially inhibited protein nitration catalyzed by both purified and endothelial-localized MPO, which was dependent on NO2 scavenging rather than MPO inhibition. Nitrogen Dioxide myeloperoxidase Homo sapiens