Pub. Date : 2021 Jun 21
PMID : 34085520
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | At this site, MPO mediates endothelial dysfunction by catalytically consuming nitric oxide (NO) and producing reactive oxidants, hypochlorous acid (HOCl) and the nitrogen dioxide radical ( NO2). | Hypochlorous Acid | myeloperoxidase | Homo sapiens |
| 2 | At this site, MPO mediates endothelial dysfunction by catalytically consuming nitric oxide (NO) and producing reactive oxidants, hypochlorous acid (HOCl) and the nitrogen dioxide radical ( NO2). | Hypochlorous Acid | myeloperoxidase | Homo sapiens |
| 3 | Nitroxides effectively inhibited the consumption of MPO"s substrate hydrogen peroxide (H2O2) and formation of HOCl catalyzed by endothelial-localized MPO, with their efficacy dependent on both nitroxide and conjugated-polyamine structure. | Hypochlorous Acid | myeloperoxidase | Homo sapiens |
| 4 | Nitroxides effectively inhibited the consumption of MPO"s substrate hydrogen peroxide (H2O2) and formation of HOCl catalyzed by endothelial-localized MPO, with their efficacy dependent on both nitroxide and conjugated-polyamine structure. | Hypochlorous Acid | myeloperoxidase | Homo sapiens |
| 5 | Novel polyamine-conjugated nitroxides, ethylenediamine-TEMPO and putrescine-TEMPO, emerged as efficacious nitroxides uniquely exhibiting high endothelial cell uptake and efficient inhibition of MPO-catalyzed HOCl production, protein nitration, and NO oxidation. | Hypochlorous Acid | myeloperoxidase | Homo sapiens |