Title : New ursolic acid derivatives bearing 1,2,3-triazole moieties: design, synthesis and anti-inflammatory activity in vitro and in vivo.

Pub. Date : 2022 Apr

PMID : 34080112






1 Functional Relationships(s)
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1 Further studies revealed that compound 11b exhibited effective COX-2 inhibitory activity, with half-maximal inhibitor concentration (IC50) value of 1.16 microM and selectivity index (SI = 64.66) value close to that of celecoxib (IC50 = 0.93 microM, SI = 65.47). Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens