Pub. Date : 2021
PMID : 34078833
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Remifentanil protects against myocardial ischemia/reperfusion injury via miR-205-mediated regulation of PINK1. | Remifentanil | microRNA 205 | Rattus norvegicus |
| 2 | However, preconditioning with remifentanil reduced miR-205 and enhanced PINK1. | Remifentanil | microRNA 205 | Rattus norvegicus |
| 3 | Moreover, over-expression of miR-205 decreased PINK1 expression and counteracted the effects of remifentanil-induced increase of cell viability and decrease of cell apoptosis in hypoxia/reoxygenation-induced cardiomyocytes. | Remifentanil | microRNA 205 | Rattus norvegicus |
| 4 | Injection with miR-205 antagomir improved remifentanil-induced decrease of infarct size and LDH (lactic acid dehydrogenase) activity in rat model with I/R injury. | Remifentanil | microRNA 205 | Rattus norvegicus |
| 5 | In conclusion, miR-205 might participate in the protective effect of remifentanil in rat myocardial I/R injury via regulation of PINK1, providing a potential target for amelioration of cardiovascular ischemic disease. | Remifentanil | microRNA 205 | Rattus norvegicus |