Title : Remifentanil protects against myocardial ischemia/reperfusion injury via miR-205-mediated regulation of PINK1.

Pub. Date : 2021

PMID : 34078833






5 Functional Relationships(s)
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1 Remifentanil protects against myocardial ischemia/reperfusion injury via miR-205-mediated regulation of PINK1. Remifentanil microRNA 205 Rattus norvegicus
2 However, preconditioning with remifentanil reduced miR-205 and enhanced PINK1. Remifentanil microRNA 205 Rattus norvegicus
3 Moreover, over-expression of miR-205 decreased PINK1 expression and counteracted the effects of remifentanil-induced increase of cell viability and decrease of cell apoptosis in hypoxia/reoxygenation-induced cardiomyocytes. Remifentanil microRNA 205 Rattus norvegicus
4 Injection with miR-205 antagomir improved remifentanil-induced decrease of infarct size and LDH (lactic acid dehydrogenase) activity in rat model with I/R injury. Remifentanil microRNA 205 Rattus norvegicus
5 In conclusion, miR-205 might participate in the protective effect of remifentanil in rat myocardial I/R injury via regulation of PINK1, providing a potential target for amelioration of cardiovascular ischemic disease. Remifentanil microRNA 205 Rattus norvegicus