Title : Protective Effect of Panduratin A on Cisplatin-Induced Apoptosis of Human Renal Proximal Tubular Cells and Acute Kidney Injury in Mice.

Pub. Date : 2021

PMID : 34078815






2 Functional Relationships(s)
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1 Co-administration of panduratin A (50 mg/kg BW) orally improved kidney function and ameliorated renal tubule injury of cisplatin by inhibiting activation of extracellular signal-regulated kinase (ERK)1/2 and caspase 3. Cisplatin mitogen-activated protein kinase 3 Homo sapiens
2 In human renal proximal tubular cells, cisplatin induced cell apoptosis by activating pro-apoptotic proteins (ERK1/2 and caspase 3), and reducing the anti-apoptotic protein (Bcl-2). Cisplatin mitogen-activated protein kinase 3 Homo sapiens